7,64 % | Avidity Partners Management LP | 6.500.328 | −324.122 | 31. 12. 2023 |
7,53 % | Deerfield Management Company, L.P. | 6.401.000 | 3.578.000 | 31. 12. 2023 |
6,25 % | Fidelity Management & Research Company LLC | 5.312.297 | 1.135.446 | 31. 12. 2023 |
5,57 % | Perceptive Advisors LLC | 4.737.194 | 1.985.799 | 9. 1. 2024 |
4,52 % | HealthCap AB | 3.840.702 | 33.455 | 18. 3. 2024 |
4,32 % | Johnson & Johnson Innovation-JJDC, Inc. | 3.670.516 | 0 | 31. 12. 2023 |
3,83 % | Varian Medical Systems, Inc. | 3.256.972 | 3.256.972 | 17. 2. 2023 |
3,67 % | OrbiMed Advisors, LLC | 3.122.770 | 0 | 31. 12. 2023 |
3,66 % | CPP Investment Board | 3.116.966 | 0 | 31. 12. 2023 |
3,47 % | Adams Street Partners, LLC | 2.947.809 | 0 | 31. 12. 2023 |
3,00 % | TPG Capital, L.P. | 2.551.794 | 0 | 31. 12. 2023 |
12,77 % | Federated Hermes Global Investment Management Corp. | 10.866.153 | 282.364 | 31. 12. 2023 |
1,84 % | Pivotal Bioventure Partners Investment Advisor LLC | 1.560.982 | 0 | 31. 12. 2023 |
1,28 % | Sphera Funds Management Ltd. | 1.085.639 | −268.619 | 31. 12. 2023 |
1,18 % | Invus Public Equities Advisors, LLC | 1.005.500 | −719.500 | 31. 12. 2023 |
1,17 % | William Blair & Company, L.L.C. (Research) | 993.855 | 993.855 | 31. 12. 2023 |
0,88 % | Wellington Management Company, LLP | 744.474 | 579.949 | 31. 12. 2023 |
0,86 % | 1832 Asset Management L.P. | 734.321 | 0 | 31. 12. 2023 |
0,68 % | Eagle Health Investments LP | 579.769 | 0 | 31. 12. 2023 |
0,68 % | Millennium Management LLC | 578.102 | −4.027 | 31. 12. 2023 |
0,59 % | Ikarian Capital LLC | 500.000 | 500.000 | 31. 12. 2023 |
0,47 % | Adage Capital Management, L.P. | 400.000 | 400.000 | 31. 12. 2023 |
0,45 % | BlackRock Institutional Trust Company, N.A. | 380.187 | 375.975 | 31. 12. 2023 |
0,37 % | Marshall Wace LLP | 318.440 | 318.440 | 31. 12. 2023 |
0,37 % | Valliant (John Fitzmaurice) | 318.147 | 0 | 17. 2. 2023 |
0,37 % | Fred Alger Management, LLC | 311.974 | 311.974 | 31. 12. 2023 |
0,35 % | Jennison Associates LLC | 301.020 | 301.020 | 31. 12. 2023 |
0,35 % | Point72 Asset Management, L.P. | 293.611 | −35.257 | 31. 12. 2023 |
0,33 % | Pier Capital, LLC | 277.111 | 277.111 | 31. 12. 2023 |
0,30 % | Walleye Capital LLC | 251.213 | 251.213 | 31. 12. 2023 |
0,29 % | Sio Capital Management, LLC | 246.036 | 0 | 31. 12. 2023 |
0,26 % | UBS Financial Services, Inc. | 223.092 | 129.783 | 31. 12. 2023 |
0,26 % | Woodline Partners LP | 222.462 | 144.427 | 31. 12. 2023 |
0,25 % | UBS O'Connor LLC | 213.107 | −61.461 | 31. 12. 2023 |
0,18 % | Schonfeld Strategic Advisors LLC | 153.792 | 153.792 | 31. 12. 2023 |
0,17 % | Morgan Stanley Smith Barney LLC | 146.328 | −19.732 | 31. 12. 2023 |
0,17 % | Privium Fund Management BV | 141.750 | 141.750 | 31. 12. 2023 |
0,16 % | Boothbay Fund Management, LLC | 133.550 | 133.550 | 31. 12. 2023 |
0,15 % | Two Sigma Investments, LP | 130.433 | 98.333 | 31. 12. 2023 |
0,15 % | Atika Capital Management LLC | 130.400 | 130.400 | 31. 12. 2023 |
0,15 % | Sofinnova Investments, Inc | 125.299 | 8.200 | 31. 12. 2023 |
0,15 % | Healthinvest Partners AB | 125.000 | 0 | 31. 12. 2023 |
0,13 % | Verition Fund Management LLC | 109.386 | 109.386 | 31. 12. 2023 |
0,10 % | Franklin Advisers, Inc. | 89.100 | 89.100 | 31. 1. 2024 |
0,10 % | Invesco Advisers, Inc. | 88.130 | 25.451 | 29. 2. 2024 |
0,10 % | Jump Financial, LLC | 86.199 | 86.199 | 31. 12. 2023 |
0,09 % | Yarbrough Capital, LLC | 76.872 | 0 | 31. 3. 2024 |
0,08 % | Cubist Systematic Strategies, LLC | 67.470 | 67.460 | 31. 12. 2023 |
0,07 % | Morgan Stanley & Co. LLC | 60.253 | 60.253 | 31. 12. 2023 |
0,07 % | BlackRock Investment Management, LLC | 59.154 | −2.263 | 29. 2. 2024 |
0,07 % | Sectoral Asset Management Inc. | 57.297 | 0 | 31. 12. 2023 |
0,07 % | Gannon (Steven R) | 56.400 | 0 | 17. 2. 2023 |
0,07 % | abrdn Investments Limited | 56.100 | 56.100 | 31. 3. 2024 |
0,06 % | Citadel Advisors LLC | 54.123 | 54.123 | 31. 12. 2023 |
0,06 % | Chartwell Investment Partners, LLC | 49.890 | 49.890 | 31. 12. 2023 |
0,06 % | Avantis Investors | 48.526 | 48.526 | 31. 3. 2024 |
0,06 % | Assenagon Asset Management S.A. | 48.138 | 3.536 | 29. 2. 2024 |
0,05 % | Superstring Capital Management LP | 45.801 | 45.801 | 31. 12. 2023 |
0,05 % | Medical Strategy GmbH | 44.000 | 44.000 | 31. 12. 2023 |
0,05 % | Tekla Capital Management LLC_NLE | 43.394 | 0 | 30. 6. 2023 |
0,05 % | Khuong (Chau Quang) | 42.093 | 0 | 17. 2. 2023 |
0,05 % | Geode Capital Management, L.L.C. | 39.346 | 8.478 | 31. 12. 2023 |
0,05 % | Burak (Eric) | 38.490 | 0 | 17. 2. 2023 |
0,05 % | BlackRock Advisors (UK) Limited | 38.391 | 1.843 | 31. 3. 2024 |
0,04 % | BlackRock Asset Management Ireland Limited | 35.578 | 35.578 | 31. 12. 2023 |
0,04 % | Raymond James Financial Services Advisors, Inc. | 31.145 | 31.145 | 31. 12. 2023 |
0,04 % | NEOS Investment Management, LLC | 30.939 | 13.446 | 31. 12. 2023 |
0,04 % | RBC Capital Markets Wealth Management | 30.669 | 30.669 | 31. 12. 2023 |
0,03 % | Jane Street Capital, L.L.C. | 28.132 | 28.132 | 31. 12. 2023 |
0,03 % | Driehaus Capital Management, LLC | 23.270 | 0 | 29. 2. 2024 |
0,03 % | XTX Markets LLC | 23.161 | 23.161 | 31. 12. 2023 |
0,03 % | The Vanguard Group, Inc. | 23.029 | 23.029 | 31. 3. 2024 |
0,03 % | Credit Suisse Funds AG | 21.867 | 21.867 | 29. 2. 2024 |
0,03 % | abrdn Inc. | 21.697 | 21.697 | 31. 12. 2023 |
0,03 % | Goldman Sachs Asset Management, L.P. | 21.605 | −170 | 31. 3. 2024 |
0,02 % | T. Rowe Price Associates, Inc. | 21.100 | 21.100 | 29. 2. 2024 |
0,02 % | Raymond James & Associates, Inc. | 20.200 | 20.200 | 31. 12. 2023 |
0,02 % | Federated Hermes Equity Management Company of Pennsylvania | 20.000 | −80.000 | 31. 12. 2023 |
0,02 % | Group One Trading, L.P. | 19.134 | 19.134 | 31. 12. 2023 |
0,02 % | Susquehanna International Group, LLP | 18.465 | 18.465 | 31. 12. 2023 |
0,02 % | ProShare Advisors LLC | 17.623 | 12.213 | 31. 3. 2024 |
0,02 % | Forefront Analytics, LLC | 16.715 | −16.970 | 31. 12. 2023 |
0,02 % | Belvedere Trading, LLC | 16.349 | 16.349 | 31. 12. 2023 |
0,02 % | Alpine Associates Management Inc. | 15.700 | 15.700 | 31. 3. 2024 |
0,02 % | Goldman Sachs & Company, Inc. | 15.132 | 15.132 | 31. 12. 2023 |
0,02 % | Rawat (Mohit) | 12.843 | 12.843 | 31. 8. 2023 |
0,01 % | Squarepoint Capital LLP | 12.757 | 12.757 | 31. 12. 2023 |
0,01 % | Simplex Trading, LLC | 12.501 | 12.422 | 31. 12. 2023 |
0,01 % | Leamon (Christopher Paul Ph.D.) | 11.957 | 11.957 | 31. 8. 2023 |
0,01 % | Envestnet Asset Management, Inc. | 11.454 | 11.454 | 31. 12. 2023 |
0,01 % | Crowley (John Joseph CPA) | 10.410 | 0 | 17. 2. 2023 |
0,01 % | Vanguard Investments Australia Ltd. | 10.380 | 10.380 | 29. 2. 2024 |
0,01 % | Renaissance Technologies LLC | 10.000 | 10.000 | 31. 12. 2023 |
0,01 % | AlphaSimplex Group, LLC | 9.590 | 9.590 | 29. 2. 2024 |
0,01 % | Preston (Heather Elizabeth) | 8.823 | 0 | 17. 2. 2023 |
0,01 % | Cutler Group, LP | 8.600 | 7.500 | 31. 3. 2024 |
0,01 % | Mercer Global Investments Management Ltd | 8.600 | 8.600 | 31. 3. 2024 |
0,01 % | State Street Global Advisors Ireland Limited | 8.500 | 8.500 | 31. 3. 2024 |
0,01 % | American Century Investment Management, Inc. | 8.399 | 8.399 | 31. 3. 2024 |
0,01 % | China Universal Asset Management Co., Ltd. | 8.376 | 8.376 | 31. 12. 2023 |